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MitoTam (bromide, hydrobromide)

CAT: 0804-HY-126222Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126222Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MitoTam bromide, hydrobromide, a Tamoxifen derivative[1], is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology[2]. MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells[1][2].
CAS Number
1634624-73-9
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mitotam-bromide-hydrobromide.html
Purity
98.24
Solubility
DMSO : 240 mg/mL (ultrasonic)
Smiles
CN(CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CCCCCCCCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C=C1)C.Br[H].[Br-]
Molecular Formula
C52H60Br2NOP
Molecular Weight
905.82
References & Citations
[1]Rohlenova K, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2highBreast Cancer. Antioxid Redox Signal. 2017 Jan 10;26 (2) :84-103.|[2]Hubackova S, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019 Jan;26 (2) :276-290.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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