MS-073

MS-073

• CAS Number: 129716-45-6
• UNSPSC Description: MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].
• Target Antigen: P-glycoprotein
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ms-073.html
• Smiles: OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46
• Molecular Weight: 479.61
• References & Citations: [1]Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51(9): 2420-2424.|[2]Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298(3): 1252-1259.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported