MS-073

CAT: 0804-HY-129698Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-129698Size:1 Each
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Description
MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].
CAS Number
[129716-45-6]
Product Name Alternative
CP162398
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms-073.html
Smiles
OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46
Molecular Formula
C31H33N3O2
Molecular Weight
479.61
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51 (9) : 2420-2424.|[2]Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298 (3) : 1252-1259.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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