MS-073

• Description:

  MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].

• Product Name Alternative:

  CP162398

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  P-glycoprotein

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ms-073.html

• Smiles:

  OC (COC1=C2C=CC=NC2=CC=C1) CN3CCN (CC3) C4C5=CC=CC=C5CCC6=CC=CC=C46

• Molecular Formula:

  C31H33N3O2

• Molecular Weight:

  479.61

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51 (9) : 2420-2424.|[2]Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298 (3) : 1252-1259.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  129716-45-6