MS-073

• Description :

  MS-073 (CP162398) is a P-glycoprotein (P-gp) inhibitor. MS-073 reverses multidrug resistance in drug-resistant cells by competitively inhibiting drug binding to P-glycoprotein[1][2].

• Product Name Alternative :

  CP162398

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  P-glycoprotein

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ms-073.html

• Smiles :

  OC(COC1=C2C=CC=NC2=CC=C1)CN3CCN(CC3)C4C5=CC=CC=C5CCC6=CC=CC=C46

• Molecular Formula :

  C31H33N3O2

• Molecular Weight :

  479.61

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]Sato W, et al. Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073[J]. Cancer research, 1991, 51 (9) : 2420-2424.|[2]Smith B J, et al. P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists[J]. Journal of Pharmacology and Experimental Therapeutics, 2001, 298 (3) : 1252-1259.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [129716-45-6]