GATA3 Recombinant Mouse Monoclonal Antibody [PD00-41]

GATA3 Recombinant Mouse Monoclonal Antibody [PD00-41]

• Description: GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes. The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. GATA3 haploinsufficiency (i.e. lose of one or the two inherited GATA3 genes) results in a congenital disorder termed the Barakat syndrome. Current clinical and laboratory research is focusing on determining the benefits of directly or indirectly blocking the action of GATA3 in inflammatory and allergic diseases such as asthma. It is also proposed to be a clinically important marker for various types of cancer, particularly those of the breast. However, the role, if any, of GATA3 in the development of these cancers is under study and remains unclear.
• Product Name Alternative: GATA 3 antibody GATA binding factor 3 antibody GATA binding protein 3 antibody GATA-binding factor 3 antibody Gata3 antibody GATA3_HUMAN antibody HDR antibody HDRS antibody MGC2346 antibody MGC5199 antibody MGC5445 antibody Trans acting T cell specific transcription factor GATA 3 antibody Trans-acting T-cell-specific transcription factor GATA-3 antibody
• Abbreviation: Trans-acting T-cell-specific transcription factor GATA-3,GATA-binding factor 3
• CAS Number: 9000-83-3
• Swiss Prot: P23771 Human
• Cellular Locus: Nucleus.
• Host: Mouse
• Species Reactivity: Human
• Immunogen: Synthetic peptide.
• Isotype: IgG2c
• Clone: PD00-41
• Conjugation: Non-conjugated
• Type: Recombinant Mouse monoclonal Antibody
• Applications: WB, IHC-P, IF-Cell
• Positive Control: MCF7 cell lysate, Jurkat cell lysate, human breast carcinoma tissue, human breast tissue, human kidney tissue, SH-SY5Y.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:200-1:1,000 ;IF-Cell: 1:50
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 48 kDa.
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes