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Deferoxamine-DBCO

CAT: 0804-HY-158067-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-158067-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Deferoxamine-DBCO is a bifunctional chelating agent. Deferoxamine-DBCO efficiently chelates with radioactive metals (such as 89Zr) through the DFO structure to achieve radiolabeling. Deferoxamine-DBCO undergoes a metal-free Huisgen cycloaddition reaction with azide-containing biomolecules (such as siRNA, monoclonal antibodies) under bioorthogonal conditions through the DBCO structure to achieve targeted coupling. Deferoxamine-DBCO has efficient metal chelating ability and specific bioorthogonal reaction activity. Deferoxamine-DBCO can be used for targeted radioactive imaging studies of tumors[1][2][3].
CAS Number
2359695-48-8
Product Name Alternative
DFO-DBCO
UNSPSC
12352200
Target
Biochemical Assay Reagents; Radionuclide-Drug Conjugates (RDCs)
Type
Biochemical Assay Reagents
Related Pathways
Antibody-drug Conjugate/ADC Related; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/deferoxamine-dbco.html
Purity
94.38
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N(CCCCCNC(CCC(N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3)=O)=O)O)=O)=O)O)=O)=O)O)=O
Molecular Formula
C44H61N7O10
Molecular Weight
848.00
References & Citations
[1]Sales ZS, et al. Practical syntheses of DOTAGA-DBCO and DFO-DBCO, strained alkyne pre-cursors to radioimmunoconjugates for targeted alpha therapy. Bioorg Med Chem. 2022 Nov 1;73:117010. |[2]Hofstraat SRJ, et al. Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors. Nat Nanotechnol. 2025 Apr;20 (4) :532-542. |[3]Huang F Y J, et al. Preparation and Characterization of Site-Specifically Radiolabeled 89Zr-DFO-anti-PD-L1-mAb ImmunoPET Tracer[J]. 2023.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator

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