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Mal-Deferoxamine

CAT: 0804-HY-132989-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132989-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mal-Deferoxamine is a maleamide (Mal) -containing Deferoxamine. Mal selectively covalently binds to sulfur groups to produce a linking reaction. Mal-Deferoxamine can be combined with radionuclides to synthesize radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.[1].
CAS Number
1638156-31-6
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; HIF/HIF Prolyl-Hydroxylase; Radionuclide-Drug Conjugates (RDCs) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal-deferoxamine.html
Purity
95.0
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=CC(N1CCC(NCCCCCN(C(CCC(NCCCCCN(C(CCC(NCCCCCN(C(C)=O)O)=O)=O)O)=O)=O)O)=O)=O
Molecular Formula
C32H53N7O11
Molecular Weight
711.80
References & Citations
[1] Summer D, et al. Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression. Mol Pharm. 2018;15 (1) :175-185.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator

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