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Desvenlafaxine

CAT: 0804-HY-B0602-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0602-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine , is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].
CAS Number
93413-62-8
Product Name Alternative
O-Desmethylvenlafaxine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/desvenlafaxine.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C(C2(O)CCCCC2)CN(C)C)C=C1
Molecular Formula
C16H25NO2
Molecular Weight
263.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318 (2) : p. 657-65.|[2]Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42 (10) : p. 1439-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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B2236-25Desvenlafaxine
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NMA47175Desvenlafaxine fumarate
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527773Desvenlafaxine HCl

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