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CHPG

CAT: 0804-HY-101364-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101364-01Size:5 mg
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Description
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
CAS Number
[170846-74-9]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Akt; ERK; mGluR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/chpg.html
Purity
99.51
Solubility
1M NaOH : 25 mg/mL (ultrasonic; adjust pH to 11 with NaOH) |DMSO : 25 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)
Smiles
O=C(O)C(N)C1=CC(O)=CC=C1Cl
Molecular Formula
C8H8ClNO3
Molecular Weight
201.61
Precautions
H302, H312, H332
References & Citations
2
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK; mGluR5; NF-κB
Citation 01
IBRO Neurosci Rep. 2025 May 26:18:823-829.|World J Gastroenterol. 2025 Feb 21;31 (7) :98852. |Immunobiology. 2025 Jun 28;230 (4) :153095.|SSRN. 2025 Aug 27.

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