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Plecanatide (acetate)

CAT: 0804-HY-108741A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108741A-01Size:1 mg
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Description
Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis[1][2][3].
CAS Number
1075732-84-1
UNSPSC
12352209
Target
Guanylate Cyclase
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Plecanatide_acetate.html
Purity
99.51
Solubility
DMSO : 3 mg/mL (ultrasonic)
Smiles
NC(C[C@H](N)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@](C(NCC(N[C@@H](CSSC2)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)([H])[C@H](O)C)=O)([H])CSSC1)=O)C)=O)C(C)C)=O)CC(N)=O)=O)C(C)C)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)=O)=O)=O.CC(O)=O
Molecular Formula
C67H108N18O28S4
Molecular Weight
1741.94
References & Citations
[1]Shailubhai K, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6 (4) :213-22.|[2]Rao SSC. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018 Jun 8;11:1756284818777945.|[3]Shailubhai K, et, al. Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe. Dig Dis Sci. 2013 Sep;58 (9) :2580-6.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Launched

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