Plecanatide

Plecanatide

• CAS Number: 467426-54-6
• UNSPSC Description: Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis[1][2][3].
• Target Antigen: Guanylate Cyclase
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology; Cancer
• Assay Protocol: https://www.medchemexpress.com/plecanatide.html
• Purity: 99.75
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: NC(C[C@H](N)C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@]2([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@@](C(NCC(N[C@@H](CSSC2)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)([H])[C@H](O)C)=O)([H])CSSC1)=O)C)=O)C(C)C)=O)CC(N)=O)=O)C(C)C)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)=O)=O)=O
• Molecular Weight: 1681.89
• References & Citations: [1]Shailubhai K,et, al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22.|[2]Rao SSC. Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation. Therap Adv Gastroenterol. 2018 Jun 8;11:1756284818777945.|[3]Shailubhai K, et, al. Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe. Dig Dis Sci. 2013 Sep;58(9):2580-6.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: Launched