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TPM4 rabbit pAb

CAT: 0855-ES12602-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES12602-01Size:50 µL
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Background
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Description
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009],
UniProt
P67936
Swiss Prot
P67936
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human TPM4 AA range: 127-177
Target
TPM4
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton . Associates with F-actin stress fibers. .
Gene ID (Human)
7171

UniProtKB · P67936

Tropomyosin alpha-4 chain

TPM4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P67936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TPM4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
P07226, Q15659, Q5U0D9, Q9BU85, Q9H8Q3, Q9UCS1, Q9UCS2, Q9UCS3, Q9UCS4
Protein keywords

PTM

AcetylationPhosphoprotein

Molecular function

Actin-bindingMuscle protein

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Domain

Coiled coil

Cellular component

CytoplasmCytoskeleton

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variant

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