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Covidcil-19

CAT: 0804-HY-W728005-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W728005-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation[1].
CAS Number
1225177-95-6
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/covidcil-19.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NC2=NC(NC)=C3C=CC=CC3=N2)=CC=C1)O
Molecular Formula
C16H14N4O2
Molecular Weight
294.31
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Hafeez S Haniff, et al. Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders. ACS Cent Sci. 2020 Oct 28;6 (10) :1713-1721.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T71191-01Covidcil-19
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