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NCB-0846

CAT: 0804-HY-100830-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100830-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCB-0846 is an orally active, selective inhibitor for Wnt, that inhibits Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. NCB-0846 blocks TGF-β signaling pathway by inhibiting SMAD2/3 phosphorylation and nuclear translocation[1][2].
CAS Number
1792999-26-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAP4K; TGF-beta/Smad; Wnt
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NCB-0846.html
Purity
99.61
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O[C@@H](CC1)CC[C@@H]1OC2=CC=CC(C=N3)=C2N=C3NC4=CC=C(N=CN5)C5=C4
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586.|[2]Sugano T, et al., Pharmacological blockage of transforming growth factor-β signalling by a Traf2- and Nck-interacting kinase inhibitor, NCB-0846. Br J Cancer. 2021 Jan;124 (1) :228-236.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K7/TNIK

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