CDK2-IN-4

• Description:

  CDK2-IN-4 (compound 73) is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk2-in-4.html

• Purity:

  99.85

• Solubility:

  DMSO : 20.83 mg/mL (ultrasonic)

• Smiles:

  O=S (C1=CC=C (C=C1) NC2=NC3=NC=NC3=C (C4=CC (C5=CC=CC=C5) =CC=C4) N2) (N) =O

• Molecular Formula:

  C23H18N6O2S

• Molecular Weight:

  442.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Coxon CR, et al. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60 (5) :1746-1767.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1; CDK2

• CAS Number:

  2079895-42-2