Practolol-d7

• Description :

  Practolol-d7 is the deuterium labeled Practolol. Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias[1][2][3].

• UNSPSC :

  12352005

• Target :

  Adrenergic Receptor; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling; Others

• Field of Research :

  Cardiovascular Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(NC1=CC=C(OCC(O)CNC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])C=C1)=O

• Molecular Formula :

  C14H15D7N2O3

• Molecular Weight :

  273.38

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Iakovidis D, et, al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68 (4) :677-85.|[3]Adashi EY, et, al. Stimulation of beta 2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo. Endocrinology. 1981 Jun;108 (6) :2170-8.|[4]Marshall RJ, et, al. Comparative effects of propranolol and practolol in the early stages of experimental canine myocardial infarction. Br J Pharmacol. 1976 Jun;57 (2) :295-303.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2714414-11-4]