TFMB-(R)-2-HG

TFMB-(R)-2-HG

• CAS Number: 1445700-01-5
• UNSPSC Description: TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tfmb-r-2-hg.html
• Purity: 99.91
• Solubility: DMSO : 233.33 mg/mL (ultrasonic)
• Smiles: O=C([C@@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
• Molecular Weight: 288.221
• References & Citations: [1]Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported