TFMB-(S)-2-HG

TFMB-(S)-2-HG

• CAS Number: 1445703-64-9
• UNSPSC Description: TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].
• Target Antigen: DNA Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tfmb-s-2-hg.html
• Purity: 99.62
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C([C@H](CC1)OC1=O)OCC2=CC=CC(C(F)(F)F)=C2
• Molecular Weight: 288.221
• References & Citations: [1]Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported