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TM-233

CAT: 0804-HY-119009Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119009Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM-233 is an inhibitor of the JAK/STAT and NF-κB signaling pathways, exhibiting significant antitumor activity. TM-233 reduces the expression of the anti-apoptotic protein Mcl-1 by inhibiting the phosphorylation of JAK2 and STAT3, and regulates its transcription by directly binding to the Mcl-1 gene promoter. Additionally, TM-233 prevents the translocation of NF-κB from the cytoplasm to the nucleus by inhibiting its DNA-binding activity, thereby reducing nuclear NF-κB expression. TM-233 shows potential in overcoming Bortezomib resistance and can be applied in research related to multiple myeloma[1].
CAS Number
1103745-28-3
UNSPSC
12352005
Target
Bcl-2 Family; JAK; NF-κB; STAT
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tm-233.html
Smiles
CC(OC(C1=CC=C(C=C1)OC(C)=O)C2=C3C=CC=CC3=CC4=CC=CC=C24)=O
Molecular Formula
C25H20O4
Molecular Weight
384.42
References & Citations
[1]Sagawa M, et al. TM-233 Exerts Anti-Myeloma Activity and Overcomes Bortezomib-Resistance In Human Multiple Myeloma Cells By Targeting NF-κB and JAK/STAT Dual-Signaling Pathways[J]. Blood, 2013, 122 (21) : 4427.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; Mcl-1; STAT3

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