BCOR(498-514), biotinylated

• UNSPSC Description:

  BCOR(498-514), biotinylated is the minimal BCL6 binding domain with an KD value of 1.32 µM. BCOR(498-514), biotinylated blocks BCL6-mediated transcriptional repression and kills lymphoma cells[1].

• Target Antigen:

  BCL6

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bcor-498-514-biotinylated.html

• Smiles:

  O=C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N4[C@@H](CCC4)C(NCC(N5[C@@H](CCC5)C(N[C@@H](CCCCNC(CCCC[C@@H]6SC[C@]([C@]6([H])N7)([H])NC7=O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(NC(C)=O)=N)N

• Molecular Weight:

  2179.49

• References & Citations:

  [1]Ghetu AF, et al. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. Mol Cell. 2008 Feb 15;29(3):384-91.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported