Toxin A from Clostridium difficile

• Description:

  Toxin A from Clostridium difficile_x000D_ Catalog number: B2017381_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: 2-8°C_x000D_ Keywords: TcdA_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Kuehne SA, Cartman ST, Heap JT, Kelly ML, Cockayne A, Minton NP. The role of toxin A and toxin B in Clostridium difficile infection Nature. 2010 Oct 7;467(7316):711-3._x000D_ 2: Chandrasekaran R, Lacy DB. The role of toxins in Clostridium difficile infection FEMS Microbiol Rev. 2017 Nov 1;41(6):723-750._x000D_ 3: Aktories K, Papatheodorou P, Schwan C. Binary Clostridium_difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton Anaerobe. 2018 Oct;53:21-29._x000D_ 4: Willing SE, Richards EJ, Sempere L, Dale AG, Cutting SM, Fairweather NF. Increased toxin expression in a Clostridium_difficile mfd mutant BMC Microbiol. 2015 Dec 18;15:280._x000D_ 5: Alvin JW, Lacy DB. Clostridium_difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue J Struct Biol. 2017 Jun;198(3):203-209._x000D_ 6: Drudy D, Fanning S, Kyne L. Toxin A-negative, toxin B-positive Clostridium_difficile Int J Infect Dis. 2007 Jan;11(1):5-10._x000D_ 7: Carter GP, Rood JI, Lyras D. The role of toxin_A and toxin_B in the virulence of Clostridium_difficile Trends Microbiol. 2012 Jan;20(1):21-9._x000D_ 8: Weiss K. Toxin-binding treatment for Clostridium difficile: a review including reports of studies with tolevamer Int J Antimicrob Agents. 2009 Jan;33(1):4-7._x000D_ 9: Fiorentini C, Thelestam M. Clostridium difficile_toxin_A and its effects on cells Toxicon. 1991;29(6):543-67._x000D_ 10: Aldape MJ, Heeney DD, Bryant AE, Stevens DL. Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile J Antimicrob Chemother. 2015 Jan;70(1):153-9. _x000D_ _x000D_ Products Related to Toxin A from Clostridium difficile can be found at Proteins

• Short Description:

  Catalog Number: B2017381 (100 µg)_x000D_ Toxin A, also known as TcdA, is a major virulence factor produced by Clostridium difficile (C. difficile), a Gram-positive, spore-forming bacterium causing severe gastrointestinal conditions. Toxin A is an enterotoxin that disrupts intestinal epithelial cells, induces a strong inflammatory response, and works synergistically with Toxin B (TcdB) to cause disease. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5