Diphtheria Toxin (unnicked) from Corynebacterium diphtheriae

• Description:

  Diphtheria Toxin (unnicked) from Corynebacterium diphtheriae_x000D_ Catalog number: B2017279_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 1 mg_x000D_ Molecular Weight or Concentration: N/A_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: N/A_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Parveen S, Bishai WR, Murphy JR. Corynebacterium diphtheriae: Diphtheria Toxin, the tox Operon, and Its Regulation by Fe2(+) Activation of apo-DtxR Microbiol Spectr. 2019 Jul;7(4):10.1128/microbiolspec.gpp3-0063-2019._x000D_ 2: Weerasekera D, Möller J, Kraner ME, Azevedo Antunes C, Mattos-Guaraldi AL, Burkovski A. Beyond diphtheria toxin: cytotoxic proteins of Corynebacterium ulcerans and Corynebacterium diphtheriae Microbiology (Reading). 2019 Aug;165(8):876-890._x000D_ 3: Fry NK, Pringle E, Newsholme W, Nicholls M, Stephenson J, Heathcock RT, Gower C, Lacy J, O'Boyle S, Litt DJ, Sheppard C, Groves N, D'Aeth J, Hopkins KL, Meunier D, De Zoysa A, Efstratiou A, Brown C, Chand M, Amirthalingam G. Household transmission of non-toxigenic diphtheria toxin gene-bearing Corynebacterium diphtheriae following a cluster of cutaneous cases in a specialist outpatient setting J Med Microbiol. 2023 Jun;72(6)._x000D_ 4: Greenfield L. Diphtheria toxin cloning and expression in Corynebacterium diphtheriae Targeted Diagn Ther. 1992;7:273-305._x000D_ 5: Muthuirulandi Sethuvel DP, Subramanian N, Pragasam AK, Inbanathan FY, Gupta P, Johnson J, Sharma NC, Hemvani N, Veeraraghavan B, Anandan S, Sangal L. Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India Indian J Med Microbiol. 2019 Jul-Sep;37(3):423-425._x000D_ 6: Prygiel M, Mosiej E, Polak M, Krysztopa-Grzybowska K, Wdowiak K, FormiÅ„ska K, Zasada AA. Challenges of Diphtheria Toxin Detection Toxins (Basel). 2024 May 26;16(6):245._x000D_ 7: Pappenheimer AM Jr. Diphtheria toxin Annu Rev Biochem. 1977;46:69-94._x000D_ 8: Doyle CJ, Mazins A, Graham RM, Fang NX, Smith HV, Jennison AV. Sequence Analysis of Toxin Gene-Bearing Corynebacterium diphtheriae Strains, Australia Emerg Infect Dis. 2017 Jan;23(1):105-107._x000D_ 9: Ott L, Möller J, Burkovski A. Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells Int J Mol Sci. 2022 Mar 18;23(6):3298._x000D_ 10: Suwanpatcharakul M, Pakdeecharoen C, Visuttitewin S, Pesirikan N, Chauvatcharin S, Pongtharangkul T. Process optimization for an industrial-scale production of Diphtheria toxin by Corynebacterium diphtheriae PW8 Biologicals. 2016 Nov;44(6):534-539. _x000D_ _x000D_ Products Related to Diphtheria Toxin (unnicked) from Corynebacterium diphtheriae can be found at Proteins

• Short Description:

  Catalog Number: B2017279 (1 mg)_x000D_ Diphtheria toxin is a potent cytotoxin produced by the bacterium *Corynebacterium diphtheriae*. The toxin is a single polypeptide chain divided into two domains: A (active) and B (binding). The toxin must be cleaved by enzymes to become active, allowing it to enter host cells and inhibit protein synthesis, leading to cell death. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5