O12-D3-I3

• Description:

  O12-D3-I3 is an ionizable cationic lipid. O12-D3-I3 can be used in the generation of lipid nanoparticles (LNPs) for siRNA delivery in vitro and in vivo. LNPs containing O12-D3-I3 enhances LNP endosomal escape for ferroptosis RNAi therapy of cancer[1].

• UNSPSC:

  12352211

• Target:

  Liposome

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  O=C(C(CC1=CNC=N1)N)NCCCN(CCC(OCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCC)=O

• Molecular Formula:

  C39H73N5O5

• Molecular Weight:

  692.03

• References & Citations:

  [1]Liu Y, et al. Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer. Small. 2024 Oct;20 (40) :e2402362.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported