MS-1020

CAT: 0804-HY-123099-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123099-01Size:1 mg
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Description
MS-1020 is a potent and ATP-competitive JAK3 inhibitor. MS-1020 inhibits JAK3/STAT signaling and induces apoptosis. MS-1020 promotes cell death. MS-1020 decreases the expression of tyrosine phosphorylated STAT3 levels. MS-1020 has the potential for the research of cancers harboring aberrant JAK3 signaling[1].
CAS Number
[1255516-86-9]
UNSPSC
12352005
Hazard Statement
H302-H319
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms-1020.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C2C=CC=CC2=C1O)NCCC3=CNC4=C3C=C(O)C=C4
Molecular Formula
C21H18N2O3
Molecular Weight
346.38
Precautions
P264-P270-P280-P330-P501
References & Citations
[1]Kim BH, et al. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148 (1) :132-43.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3

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