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Dapivirine-d4

CAT: 0804-HY-14266S1Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14266S1Size:1 Each
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Description
Dapivirine-d4 (TMC120-d4) is deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI) . Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations[1][2][3].
CAS Number
1309283-15-5
Product Name Alternative
TMC120-d4; R147681-d4
UNSPSC
12352005
Target
Apoptosis; Autophagy; HIV; Isotope-Labeled Compounds; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
N#CC1=C([2H])C([2H])=C(NC2=NC=CC(NC3=C(C)C=C(C)C=C3C)=N2)C([2H])=C1[2H]
Molecular Formula
C20H15D4N5
Molecular Weight
333.42
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Weiwen Liu, et al. Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma. J Cancer. 2018 Jan 1;9 (1) :117-128.|[3]Bríd Devlin, et al. Development of dapivirine vaginal ring for HIV prevention. Antiviral Res. 2013 Dec;100 Suppl:S3-8.|[4]Yven Van Herrewege, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48 (1) :337-9.|[5]Michael E Halwes, et al. Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci. 2016 Oct 10;93:410-8.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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