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PAR4 antagonist 4

CAT: 0804-HY-162409Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162409Size:1 Each
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Description
PAR4 antagonist 4 (Compound 37) is a selective antagonist for protease activated receptor 4 (PAR4) . PAR4 antagonist 3 exhibits antiplatelet efficacy with IC50 of 14.2 nM. PAR4 antagonist 3 improves metabolic stablility in human liver microsomes with T1/2 of 42.5 min[1].
CAS Number
3057206-41-1
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(OCC2OC3=CC=C4C(OC(C5=CN6C(SC(OC)=N6)=N5)=C4)=C3OC2)C=C1
Molecular Formula
C22H16FN3O5S
Molecular Weight
453.44
References & Citations
[1]Chen P, et al., Discovery of 2,3-Dihydro[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity and Low Bleeding Tendency. J Med Chem. 2024 Apr 11;67 (7) :5502-5537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR4

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