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Ras Inhibitory Peptide

CAT: 0804-HY-P2157-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2157-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ras Inhibitory Peptide (VPPPVPPRRR) is a Ras inhibitor with antitumor activity[1].
CAS Number
159088-48-9
UNSPSC
12352209
Target
Ras
Type
Peptides
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ras-inhibitory-peptide.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C([C@@H](N)C(C)C)=O)N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@@H](C(C)C)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C53H91N19O11
Molecular Weight
1170.41
References & Citations
[1]Pei-Yin Ho, et al. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Mol Cancer Ther. 2006 Dec;5 (12) :3130-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Ras inhibitory peptide
CAS Number159088-48-9
PubChem CID444408
IUPAC Name(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular FormulaC53H91N19O11
Molecular Weight1170.4
XLogP-5.4
Topological Polar Surface Area474
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count15
Rotatable Bond Count28
Heavy Atom Count83
Formal Charge0
Complexity2430
SMILES
CC(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N3CCC[C@H]3C(=O)N[C@@H](C(C)C)C(=O)N4CCC[C@H]4C(=O)N5CCC[C@H]5C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N
InChI
InChI=1S/C53H91N19O11/c1-29(2)39(54)48(80)71-27-11-19-37(71)47(79)70-26-10-18-36(70)45(77)69-25-9-17-35(69)44(76)67-40(30(3)4)49(81)72-28-12-20-38(72)46(78)68-24-8-16-34(68)43(75)65-32(14-6-22-62-52(57)58)41(73)64-31(13-5-21-61-51(55)56)42(74)66-33(50(82)83)15-7-23-63-53(59)60/h29-40H,5-28,54H2,1-4H3,(H,64,73)(H,65,75)(H,66,74)(H,67,76)(H,82,83)(H4,55,56,61)(H4,57,58,62)(H4,59,60,63)/t31-,32-,33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
InChIKey
KDEHBKGSNFLJSF-QMAXXTOWSA-N
Chemical Structure
2D Structure
2D structure of Ras inhibitory peptide
CAS: 159088-48-9
CID: 444408
Formula: C53H91N19O11
MW: 1170.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1170.4
XLogP3-5.4
Hydrogen Bond Donor Count12
Hydrogen Bond Acceptor Count15
Rotatable Bond Count28
Exact Mass1169.71454480
Monoisotopic Mass1169.71454480
Topological Polar Surface Area474 Ų
Heavy Atom Count83
Formal Charge0
Complexity2430
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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