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S21-1011

CAT: 0804-HY-161643Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161643Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
S21-1011 is a selective inhibitor for butyrylcholinesterase (BChE), with IC50 of 0.059 and 0.162 μM, for eqBChE and hBChE, respectively. S21-1011 exhibits good blood-brain barrier (BBB) permeability and good pharmacokinetic characters. S21-1011 exhibits anti-inflammatory activity through activation of keap1-Nrf2-ARE pathway (EC50 is 23.48 μM for antioxidant element ARE activation), ameliorates cognitive impairment in murine Alzheimer’s disease model[1].
CAS Number
2671859-87-1
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Keap1-Nrf2
Type
Reference compound
Related Pathways
Neuronal Signaling; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s21-1011.html
Smiles
CCCC1=CC=C(C(NC2=CN=C(C=CC=C3)C3=C2N4CCN(CC5=CC=CC=C5)CC4)=O)C=C1
Molecular Formula
C30H32N4O
Molecular Weight
464.60
References & Citations
[1]Chen Y, et al., Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease. Eur J Med Chem. 2024 Jun 5;272:116463.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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