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(R) -Funapide

CAT: 0804-HY-16723A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16723A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Funapide ((R) -TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent inhibitor of the sodium channel Nav1.7, Nav1.8 and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent[1][2].
CAS Number
1259933-15-7
Product Name Alternative
(R) -TV 45070; (R) -XEN402
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-funapide.html
Purity
99.22
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
O=C([C@@]12COC3=C1C=C(OCO4)C4=C3)N(CC5=CC=C(C(F)(F)F)O5)C6=C2C=CC=C6
Molecular Formula
C22H14F3NO5
Molecular Weight
429.35
References & Citations
[1]Sharan K Bagal, et al. Recent progress in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug 15;24 (16) :3690-9.|[2]Kitano Y, et al. Inhibition of NaV1.7: the possibility of ideal analgesics. RSC Med Chem. 2022 Aug 1;13 (8) :895-920.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7; Nav1.8

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