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L 743310

CAT: 0804-HY-117952Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117952Size:1 Each
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Description
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis[1].
CAS Number
187724-86-3
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-743310.html
Smiles
C[N+]1(CC2)CCC2(NC(NC(CC3=CNC4=C3C=CC=C4)C(CCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)=O)CC1.[Br-]
Molecular Formula
C30H33BrF6N4O2
Molecular Weight
675.50
References & Citations
[1]Tachykinin NK1 Receptor Antagonists Act Centrally to Inhibit Ernesis Induced by the Chemotherapeutic Agent Cisplatin in Ferrets
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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