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G6PD activator AG1

CAT: 0804-HY-123962-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123962-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G6PD activator AG1 is a potent and selective glucose-6-phosphate dehydrogenase (G6PD) agonist with an EC50 of 3 μM. G6PD is an oxidoreductase that catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone and the simultaneous reduction of NAD phosphate (NADP) to reduced NADP (NADPH) . G6PD activator AG1 can reduce hemolysis of human erythrocytes[1][2].
CAS Number
421581-52-4
UNSPSC
12352005
Target
NADPH Oxidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/g6pd-activator-ag1.html
Purity
99.54
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
C1(CCNCCSSCCNCCC2=CNC3=C2C=CC=C3)=CNC4=C1C=CC=C4
Molecular Formula
C24H30N4S2
Molecular Weight
438.65
References & Citations
[1]https://patents.google.com/patent/WO2019023264A1/en?oq=WO2019023264A1|[2]Kaitlyn Ryan, et al. Current investigations on clinical pharmacology and therapeutics of Glucose-6-phosphate dehydrogenase deficiency. Pharmacol Ther. 2020 Dec 14;222:107788.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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