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NDs-IN-1

CAT: 0804-HY-158334Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158334Size:1 Each
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Description
(Neurodegenerative diseases) NDs-IN-1 (Compound 3g) inhibits the activities of key enzymes such as hBACE-1, hAChE and hMAO-B. NDs-IN-1 is a novel non-covalent multi-target inhibitor. NDs-IN-1 is mainly used in the study of neurodegenerative diseases[1].
CAS Number
3033806-97-9
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Dihydroorotate Dehydrogenase; Indoleamine 2,3-Dioxygenase (IDO) ; Monoamine Oxidase; NO Synthase; p38 MAPK; PARP; Phospholipase; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nds-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C2=NN=C3C4=CC=CC=C4CCC3=C2)C=C1OC
Molecular Formula
C20H18N2O2
Molecular Weight
318.37
References & Citations
[1]Mousavi H et al. Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl (or heteroaryl) -5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases. ACS Chem Neurosci. 2024 May 1;15 (9) :1828-1881.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; IDO1; iNOS; MAO-A; MAO-B; nNOS; p38 MAPK; PARP1; PARP2; RIPK1

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