VU0152099

• Description :

  VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1].

• Product Name Alternative :

  (S)​-​(+)​-​Abscisic acid-d6; ABA-d16, 4-Hydroxy-TEMPO

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/vu0152099.html

• Purity :

  98.39

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCC3=CC=C(OCO4)C4=C3

• Molecular Formula :

  C18H17N3O3S

• Molecular Weight :

  355.41

• Precautions :

  H315, H319

• References & Citations :

  [1]Ashley E Brady, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327 (3) :941-53.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAChR4

• CAS Number :

  [612514-42-8]