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VU0152099

CAT: 0804-HY-119226-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119226-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0152099 is a potent, selective and brain-penetrant mAChR M4 positive allosteric modulator with an EC50 of 0.4 μM for rat M4 receptor. VU0152099 is inactive for other mAChR subtypes or other GPCRs. VU0152099 has no agonist activity but potentiated responses of M4 to acetylcholine[1].
CAS Number
612514-42-8
Product Name Alternative
(S)​-​(+)​-​Abscisic acid-d6; ABA-d16, 4-Hydroxy-TEMPO
UNSPSC
12352005
Hazard Statement
H315, H319
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0152099.html
Purity
98.39
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N)C2=C(C)C=C(C)N=C2S1)NCC3=CC=C(OCO4)C4=C3
Molecular Formula
C18H17N3O3S
Molecular Weight
355.41
Precautions
H315, H319
References & Citations
[1]Ashley E Brady, et al. Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 2008 Dec;327 (3) :941-53.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4

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