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2G-HaloAUTAC

CAT: 0804-HY-160902Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-160902Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2G-HaloAUTAC (Compound tt44) is a second-generation autophagy-targeting chimera (2G-HaloAUTAC) that improves the activity of AUTACs by replacing the L-Cysteine ​​ (L-Cys) linker with other structures. 2G-HaloAUTAC exhibits degradation activity against EGFP-HaloTag protein through an autophagic mechanism[1].
CAS Number
2241668-58-4
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2g-haloautac.html
Smiles
O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCOCCOCCOCCOCCOCCCCCCCl)N=C4)N
Molecular Formula
C31H43ClFN7O6
Molecular Weight
664.17
References & Citations
[1]Takahashi D, et al., Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66 (17) :12342-12372.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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