8α-Hydroxyhirsutinolide

8α-Hydroxyhirsutinolide

• CAS Number: 1394156-45-6
• UNSPSC Description: 8α-Hydroxyhirsutinolide is a sesquiterpene lactone. 8α-Hydroxyhirsutinolide inhibits TNF-α-induced NF-κB activity (IC50: 1.9 μM) and NO production. 8α-Hydroxyhirsutinolide can be isolated from Vernonia cinerea[1].
• Target Antigen: NF-κB
• Type: Natural Products
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/8α-hydroxyhirsutinolide.html
• Solubility: 10 mM in DMSO
• Smiles: OCC1=C2/C(OC1=O)=C\[C@@]3(O[C@]([C@@H](C[C@@H]2O)C)(CC3)O)C
• Molecular Weight: 296.32
• References & Citations: [1]Youn UJ, et al. Anti-inflammatory sesquiterpene lactones from the flower of Vernonia cinerea. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5559-62.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported