Recombinant Mouse CD27/TNFRSF7 Protein(Fc Tag)

Recombinant Mouse CD27/TNFRSF7 Protein(Fc Tag)

• Background: CD27 , also known as TNFRSF7 , is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage , and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer , CD27 has been shown to play roles in lymphoid proliferation , differentiation , and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule , the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity , and meanwhile , plays a key role in regulating B-cell differentiation , activation and immunoglobulin synthesis.
• Abbreviation: CD27/TNFRSF7
• Synonyms: Tnfrsf, Tnfrsf7, Cd27, T14, S152, TNFRSF7, CD27 antigen, CD27L receptor, S152, T-cell activation antigen CD27, Tp55, Tumor necrosis factor receptor superfamily member 7
• CAS Number: 9000-83-3
• UniProt: P41272
• Accession Number: P41272
• Host: Mammalian
• Origin Species: Mouse
• Tag: C-Fc
• Sequence: Pro24-Arg182
• Purity: > 90% as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
• Molecular Weight: 60 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.