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SMN-C2

CAT: 0804-HY-124648-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124648-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research[1].
CAS Number
1446311-56-3
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/smn-c2.html
Purity
98.85
Solubility
DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C(C2=CN3C(C(C)=NC(C)=C3)=N2)=CC4=CC=C(N5C[C@H](C)N(CC)CC5)C=C4O1
Molecular Formula
C24H27N5O2
Molecular Weight
417.50
References & Citations
[1]Jingxin Wang, et al. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proc Natl Acad Sci U S A. 2018 May 15;115 (20) :E4604-E4612.|[2]Nikolai A Naryshkin, et al. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 8;345 (6197) :688-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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