SMN-C2

• Description :

  SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/smn-c2.html

• Purity :

  98.85

• Solubility :

  DMSO : 7.14 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C1C(C2=CN3C(C(C)=NC(C)=C3)=N2)=CC4=CC=C(N5C[C@H](C)N(CC)CC5)C=C4O1

• Molecular Formula :

  C24H27N5O2

• Molecular Weight :

  417.50

• References & Citations :

  [1]Jingxin Wang, et al. Mechanistic studies of a small-molecule modulator of SMN2 splicing. Proc Natl Acad Sci U S A. 2018 May 15;115 (20) :E4604-E4612.|[2]Nikolai A Naryshkin, et al. Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy. Science. 2014 Aug 8;345 (6197) :688-93.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1446311-56-3]