Products for Research Use Only
RegisterLogin

Vilazodone (Hydrochloride)

CAT: 0804-HY-14261-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14261-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.
CAS Number
163521-08-2
Product Name Alternative
EMD 68843 (Hydrochloride) ; SB659746A (Hydrochloride)
UNSPSC
12352005
Hazard Statement
H361
Target
5-HT Receptor; Serotonin Transporter
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Vilazodone-Hydrochloride.html
Purity
99.94
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC(C1=CC2=C(C=CC(N3CCN(CCCCC4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O.[H]Cl
Molecular Formula
C26H28ClN5O2
Molecular Weight
477.99
Precautions
H361
References & Citations
[1]Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009|[2]Reed CR, Kajdasz DK, Whalen H, Athanasiou MC, Gallipoli S, Thase ME. The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder. Curr Med Res Opin. 2012 Jan;28 (1) :27-39.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor; mLAG-3
Citation 01
Mol Pharmacol. 2023 Nov;104 (5) :230-238.|Arch Pharm (Weinheim) . 2024 May 30:e2400263.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Nature. 2023 Dec;624 (7992) :672-681.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Mar 2:130:110911.

Chemical Information

2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1)

Vilazodone hydrochloride is a hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder. It has a role as an antidepressant, a serotonergic agonist and a serotonin uptake inhibitor. It contains a vilazodone(1+).

CAS Number163521-08-2
PubChem CID6918313
IUPAC Name5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;hydrochloride
Molecular FormulaC26H28ClN5O2
Molecular Weight478.0
Topological Polar Surface Area102
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity729
SMILES
C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N.Cl
InChI
InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H
InChIKey
RPZBRGFNBNQSOP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1)
CAS: 163521-08-2
CID: 6918313
Formula: C26H28ClN5O2
MW: 478.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass477.1931528
Monoisotopic Mass477.1931528
Topological Polar Surface Area102 Ų
Heavy Atom Count34
Formal Charge0
Complexity729
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-14262S1Vilazodone-d8 (hydrochloride)
HY-14262-01Vilazodone
HY-14261S-01Vilazodone-d8
HY-14262R-01Vilazodone (Standard)
HY-I0177-01Vilazodone carboxylic acid
HY-B0500BAlverine (hydrochloride)
HY-W714513VU0469650 (hydrochloride)
HY-W708286-01α-Pyrrolidinobutiothiophenone (hydrochloride)
HY-W492795Quifenadine (hydrochloride)
HY-W012179-01Phenylpiperazine (hydrochloride)

Alternative Products

CatalogName
A3919-5.1Vilazodone Hydrochloride
MBS132571-01Vilazodone-Hydrochloride
CS-O-17002Vilazodone-d8 Hydrochloride
A11604-10Vilazodone Hydrochloride 10mg
A11604-1000Vilazodone Hydrochloride 1g
A11604-500Vilazodone Hydrochloride 500mg
A11604-200Vilazodone Hydrochloride 200mg
A11604-100Vilazodone Hydrochloride 100mg
A11604-50Vilazodone Hydrochloride 50mg
A11604-5Vilazodone Hydrochloride 5mg

Popular Products