Vilazodone

• Description:

  Vilazodone (EMD 68843; SB 659746A) is a potent, selective and orally active serotonin reuptake inhibitor (SSRI) and partial 5-HT1A receptor agonist. Vilazodone exhibits antidepressant efficacy in vivo can be used for the research of major depressive disorder (MDD) and affective disorders[1][2].

• Product Name Alternative:

  EMD 68843; SB659746A

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor; Serotonin Transporter

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/vilazodone.html

• Purity:

  99.83

• Solubility:

  DMSO : 75 mg/mL (ultrasonic)

• Smiles:

  NC(C1=CC2=C(C=CC(N3CCN(CCCCC4=CNC5=CC=C(C=C54)C#N)CC3)=C2)O1)=O

• Molecular Formula:

  C26H27N5O2

• Molecular Weight:

  441.52

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lee A. Dawson et al. Vilazodone: A 5-HT1A Receptor Agonist/Serotonin Transporter Inhibitor for the Treatment of Affective Disorders CNS Neuroscience & Therapeutics Volume 15, Issue 2, pages 107-117, June 2009|[2]Cruz MP. Vilazodone HCl (Viibryd) : A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37 (1) :28-31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT1 Receptor; mLAG-3

• Citation 01:

  Arch Pharm (Weinheim) . 2024 May 30:e2400263.|Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Nature. 2023 Dec;624 (7992) :672-681.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Mar 2:130:110911.|Mol Pharmacol. 2023 Nov;104 (5) :230-238.

• CAS Number:

  [163521-12-8]