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DAPK1-IN-1

CAT: 0804-HY-169109-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169109-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DAPK1-IN-1 (compound 10) is a death-associated protein kinase 1 (DAPK1) inhibitor with a Kd value of 0.63 μM. DAPK1-IN-1 can be used in Alzheimer’s disease research[1].
CAS Number
1429522-04-2
UNSPSC
12352005
Target
DAPK
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dapk1-in-1.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1O)O)/C=C/C2=CC=C(C(Br)=C2)O
Molecular Formula
C15H11BrO4
Molecular Weight
335.15
References & Citations
[1]Yokoyama T, et al. Discovery and optimization of isoliquiritigenin as a death-associated protein kinase 1 inhibitor. Eur J Med Chem. 2024 Sep 4;279:116836.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dapk1-IN-1
CAS Number1429522-04-2
PubChem CID172052356
IUPAC Name(E)-3-(3-bromo-4-hydroxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one
Molecular FormulaC15H11BrO4
Molecular Weight335.15
XLogP3.9
Topological Polar Surface Area77.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity371
SMILES
C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)Br)O
InChI
InChI=1S/C15H11BrO4/c16-12-7-9(2-6-14(12)19)1-5-13(18)11-4-3-10(17)8-15(11)20/h1-8,17,19-20H/b5-1+
InChIKey
YOXIGWQDHRYVTE-ORCRQEGFSA-N
Chemical Structure
2D Structure
2D structure of Dapk1-IN-1
CAS: 1429522-04-2
CID: 172052356
Formula: C15H11BrO4
MW: 335.15
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight335.15
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass333.98407
Monoisotopic Mass333.98407
Topological Polar Surface Area77.8 Ų
Heavy Atom Count20
Formal Charge0
Complexity371
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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