Thanatin (TFA)

CAT: 0804-HY-P5601A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P5601A-01Size:1 mg
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Description
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2].
UNSPSC
12352209
Target
Bacterial; Fungal
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/thanatin-tfa.html
Purity
99.68
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H]4C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@]([H])([C@@H](C)O)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCSC)C(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CSSC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC2)=O)C(C)C)=O)CCC1)=O)CCCCN)=O)CCCCN)=O)CO)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C103H177N35O27S3.xC2HF3O2
Molecular Weight
2433.92 (free base)
References & Citations
[1]Rachita Dash, et al. Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action. Int J Mol Sci. 2021 Feb 3;22 (4) :1522. |[2]Bo Ma, et al. The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase. Nat Commun. 2019 Aug 6;10 (1) :3517.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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