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A-889425

CAT: 0804-HY-133166-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133166-01Size:5 mg
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Description
A-889425 is an oral active selective TRPV1 receptor antagonist with the with an IC50 of 335 nM (rat) and 34 nM (human). A-889425 has good penetration into the CNS and reduces mechanical allodynia and spinal neuron responses to mechanical stimulation of Complete Freund's adjuvant -inflamed rat hind paws[1][2].
CAS Number
1072921-02-8
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-889425.html
Smiles
O=C(C1=CCN(C2=NC=CC=C2C)CC1)NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3
Molecular Formula
C19H18F3N3O3S
Molecular Weight
425.42
References & Citations
[1]McGaraughty S, et al. Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats. J Neurophysiol. 2008;100 (6) :3158-3166. |[2]Brederson JD, et al. TRPV1 antagonist, A-889425, inhibits mechanotransmission in a subclass of rat primary afferent neurons following peripheral inflammation. Synapse. 2012;66 (3) :187-195.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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