Bis-Q

CAT: 0804-HY-121143Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-121143Size:1 Each
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Description
Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist) . Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially.[1].
CAS Number
[73711-18-9]
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bis-q.html
Smiles
C[N+](C)(CC1=CC=C(C=C1)/N=N/C2=CC=C(C=C2)C[N+](C)(C)C)C.[I-].[I-]
Molecular Formula
C20H30I2N4
Molecular Weight
580.29
References & Citations
[1]Activation and desensitization of acetylcholine receptors in fish muscle with a photoisomerizable agonist.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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