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Dimethothiazine (hydrochloride)

CAT: 0804-HY-A0157BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0157BSize:1 Each
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Description
Dimethothiazine hydrochloride is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine hydrochloride can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine hydrochloride can be used to research hemicrania and spasticity[1][2][3].
CAS Number
34396-64-0
Product Name Alternative
Dimetotiazine (hydrochloride) ; Fonazine (hydrochloride)
UNSPSC
12352005
Target
5-HT Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dimethothiazine-hydrochloride.html
Smiles
O=S(C1=CC=C2SC3=C(N(CC(C)N(C)C)C2=C1)C=CC=C3)(N(C)C)=O.Cl
Molecular Formula
C19H26ClN3O2S2
Molecular Weight
428.01
References & Citations
[1]Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68 (13) :839-45.|[2]Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39 (3) :520-32.|[3]Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15 (1) :25-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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