Dimethothiazine

CAT: 0804-HY-A0157Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-A0157Size:1 Each

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Description

Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity[1][2][3].

CAS Number

7456-24-8

Product Name Alternative

Dimetotiazine; Fonazine

UNSPSC

12352005

Target

5-HT Receptor; Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dimethothiazine.html

Solubility

10 mM in DMSO

Smiles

O=S(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)(N(C)C)=O

Molecular Formula

C19H25N3O2S2

Molecular Weight

391.55

References & Citations

[1]Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68 (13) :839-45.|[2]Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39 (3) :520-32.|[3]Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15 (1) :25-32.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Dimethothiazine

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