G-631

CAT: 0804-HY-164478-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-164478-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

G-631 is a selective inhibitor for tankyrase. G-631 inhibits tankyrase auto-PARsylation (poly ADP ribosylation) with an IC50 of 7 nM, and inhibits Wnt signaling pathway. G-631 exhibits good pharmacokinetic characteristics in mice[1].

CAS Number

1507370-78-6

UNSPSC

12352005

Target

PARP; Wnt

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/g-631.html

Purity

99.88

Smiles

O=C1N=C(N2CCN(CC2)C3=C(C=C(C=C3F)OCCOC)F)NC4=C1C=NN4C

Molecular Formula

C19H22F2N6O3

Molecular Weight

420.41

References & Citations

[1]Zhong Y, et al., Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1. Toxicol Pathol. 2016 Feb;44 (2) :267-78.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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G-631

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