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5-Azacytidine

CAT: 0804-HY-10586-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10586-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap DNA methyltransferases and contributes to reverse epigenetic changes[1][2]. 5-Azacytidine induces cell autophagy[4].
CAS Number
320-67-2
Product Name Alternative
Azacitidine; 5-AzaC; Ladakamycin
UNSPSC
12352005
Hazard Statement
H302, H341, H350, H360, H372, H410
Target
Antibiotic; Autophagy; Bacterial; DNA Methyltransferase; Nucleoside Antimetabolite/Analog; Organoid
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/5-Azacytidine.html
Purity
99.94
Solubility
DMSO : 250 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)N=C2)=O)O1
Molecular Formula
C8H12N4O5
Molecular Weight
244.20
Precautions
H302, H341, H350, H360, H372, H410
References & Citations
[1]Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21 (35) :5483-95.|[2]Creusot F, et al. Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidineand 5-aza-2'-deoxycytidine. J Biol Chem. 1982 Feb 25;257 (4) :2041-8.|[3]Li LH, et al. Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia. Cancer Res. 1970 Nov;30 (11) :2760-9.|[4]Marycz K, et al. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.Oxid Med Cell Longev. 2019 May 12;2019:1523140.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
DNMT1

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