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Brigatinib-13C6

CAT: 0804-HY-12857S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12857S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Brigatinib-13C6 is the 13C-labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC50 of 0.6 nM[1].
Product Name Alternative
AP-26113-13C6
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brigatinib-13c6.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(CC1)C2CCN(CC2)C3=CC=C(C(OC)=C3)NC4=NC=C(C(N[13C]5=[13CH][13CH]=[13CH][13CH]=[13C]5P(C)(C)=O)=N4)Cl
Molecular Formula
C23 13C6H39ClN7O2P
Molecular Weight
590.05
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Zhang S, et al. The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models. Clin Cancer Res. 2016 Nov 15;22 (22) :5527-5538|[3]Huang WS, et al. Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J Med Chem. 2016 May 26;59 (10) :4948-64.|[4]Siaw JT, et al. Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice. Oncotarget. 2016 May 17;7 (20) :29011-22
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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