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Glipizide-d11

CAT: 0804-HY-B0254S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0254S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) ?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium? (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].
CAS Number
1189426-07-0
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Metabolic Disease
Purity
96.36
Solubility
10 mM in DMSO
Smiles
[2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])NC(NS(=O)(C2=CC=C(C=C2)CCNC(C3=NC=C(C)N=C3)=O)=O)=O
Molecular Formula
C21H16D11N5O4S
Molecular Weight
456.60
Precautions
H302, H315, H320, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]B J Zünkler, et al. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337 (2) :225-30.|[3]Glipizide. From Wikipedia
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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