Glipizide

• Description :

  Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].

• Product Name Alternative :

  CP 28720; K 4024

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H320, H335

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/glipizide.html

• Concentration :

  10mM

• Purity :

  99.83

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  O=C(C1=NC=C(C)N=C1)NCCC2=CC=C(S(=O)(NC(NC3CCCCC3)=O)=O)C=C2

• Molecular Formula :

  C21H27N5O4S

• Molecular Weight :

  445.54

• Precautions :

  H302, H315, H320, H335

• References & Citations :

  [1]B J Zünkler, et al. Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells. Naunyn Schmiedebergs Arch Pharmacol. 1988 Feb;337 (2) :225-30.|[2]Glipizide. From Wikipedia

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [29094-61-9]