E-4031

CAT: 0804-HY-15551-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15551-01Size:5 mg
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Description
E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].
CAS Number
[113559-13-0]
UNSPSC
12352005
Hazard Statement
H302
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/E-4031.html
Purity
99.40
Solubility
H2O : ≥ 50 mg/mL
Smiles
CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O.[H]Cl.[H]Cl
Molecular Formula
C21H29Cl2N3O3S
Molecular Weight
474.44
Precautions
H302
References & Citations
[1]Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33 (8) :950-9.|[2] E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76 (4) :607-15.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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