Canrenone-d4

• Description:

  Canrenone-d4 is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

• Product Name Alternative:

  Aldadiene-d4; SC9376-d4

• UNSPSC:

  12352005

• Target:

  Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@]3(CC([2H])([2H])C(O3)=O)CC[C@@]1([H])[C@]4([H])C=CC5=CC(C([2H])([2H])C[C@]5(C)[C@@]4([H])CC2)=O

• Molecular Formula:

  C22H24D4O3

• Molecular Weight:

  344.48

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124 (2) :504-20.|[3]Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh) . 1979 Jan;90 (1) :147-56.|[4]Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277 (2) :139-49.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported